{"id":9,"date":"2026-08-03T18:25:30","date_gmt":"2026-08-03T18:25:30","guid":{"rendered":"https:\/\/biomotion.pbisllc.com\/?page_id=9"},"modified":"2026-08-05T22:16:34","modified_gmt":"2026-08-05T22:16:34","slug":"clinical-impact","status":"publish","type":"page","link":"https:\/\/biomotion.pbisllc.com\/?page_id=9","title":{"rendered":"Clinical Impact"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Parkinson&#8217;s disease affects more than 10 million people worldwide and over one million individuals in the United States. Although pharmacological treatments can alleviate symptoms, no therapy currently halts disease progression. Exercise-based rehabilitation has been shown to improve motor function &#8212; yet personalization remains limited in conventional programs.<\/p>\n\n<p class=\"wp-block-paragraph\">Adaptix Neuro builds upon a substantial body of peer-reviewed research demonstrating the benefits of motor-assisted cycling therapy.<\/p>\n\n<h2 class=\"wp-block-heading\">Early Clinical Findings<\/h2>\n\n<p class=\"wp-block-paragraph\">In pilot studies conducted by our team:<\/p>\n\n<ul class=\"wp-block-list\"><li>Participants demonstrated <strong>13% improvement in UPDRS motor scores after three sessions<\/strong><\/li><li>Improvements reached <strong>22% after twelve sessions<\/strong><\/li><\/ul>\n\n<p class=\"wp-block-paragraph\">These results are particularly significant given the non-invasive, exercise-based nature of the intervention.<\/p>\n\n<h2 class=\"wp-block-heading\">Interaction Variability and Motor Improvement<\/h2>\n\n<p class=\"wp-block-paragraph\">Our research identified a key insight: variability in cadence and power output during assisted cycling strongly correlates with motor improvement.<\/p>\n\n<p class=\"wp-block-paragraph\">Specifically:<\/p>\n\n<ul class=\"wp-block-list\"><li>Approximate Entropy (ApEn)<\/li><li>Sample Entropy (SampEn)<\/li><\/ul>\n\n<p class=\"wp-block-paragraph\">were shown to predict therapeutic response. This discovery laid the foundation for the adaptive algorithms now embedded within Adaptix Neuro.<\/p>\n\n<h2 class=\"wp-block-heading\">Objective Measurement and Validation<\/h2>\n\n<p class=\"wp-block-paragraph\">Clinical validation includes:<\/p>\n\n<ul class=\"wp-block-list\"><li>Use of UPDRS motor scoring<\/li><li>Integration with wearable motion sensors such as Kinesia One<\/li><li>Monitoring of physiological signals to ensure safety<\/li><\/ul>\n\n<p class=\"wp-block-paragraph\">Our Phase I objectives focus on validating real-time adaptive control strategies in lab-based studies with Parkinson&#8217;s disease participants, comparing adaptive therapy to static pre-set exercise protocols.<\/p>\n\n<h2 class=\"wp-block-heading\">Beyond Parkinson&#8217;s Disease<\/h2>\n\n<p class=\"wp-block-paragraph\">While Parkinson&#8217;s disease is our initial target population, the broader neurological rehabilitation market includes:<\/p>\n\n<ul class=\"wp-block-list\"><li>Stroke survivors<\/li><li>Individuals with multiple sclerosis<\/li><li>Patients with motor neuron disorders<\/li><li>Aging populations experiencing mobility decline<\/li><\/ul>\n\n<p class=\"wp-block-paragraph\">The adaptive framework developed by BioMotion allows expansion into these domains without fundamental redesign.<\/p>\n\n<h2 class=\"wp-block-heading\">Toward Scalable, Intelligent Rehabilitation<\/h2>\n\n<p class=\"wp-block-paragraph\">Our long-term vision is to enable:<\/p>\n\n<ul class=\"wp-block-list\"><li>Clinic-based deployment under therapist supervision<\/li><li>Home-based rehabilitation with remote monitoring<\/li><li>Data-driven therapy optimization at scale<\/li><\/ul>\n\n<p class=\"wp-block-paragraph\">By combining clinical evidence, advanced control systems, and machine learning, BioMotion aims to redefine how neurorehabilitation therapy is delivered &#8212; making it more personalized, effective, and accessible.<\/p>","protected":false},"excerpt":{"rendered":"<p>Clinical impact and evidence: peer-reviewed research, pilot findings, and the entropy-based metrics that predict therapeutic response.<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"page-templates\/content.php","meta":{"footnotes":""},"class_list":["post-9","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/biomotion.pbisllc.com\/index.php?rest_route=\/wp\/v2\/pages\/9","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biomotion.pbisllc.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/biomotion.pbisllc.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/biomotion.pbisllc.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biomotion.pbisllc.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9"}],"version-history":[{"count":1,"href":"https:\/\/biomotion.pbisllc.com\/index.php?rest_route=\/wp\/v2\/pages\/9\/revisions"}],"predecessor-version":[{"id":64,"href":"https:\/\/biomotion.pbisllc.com\/index.php?rest_route=\/wp\/v2\/pages\/9\/revisions\/64"}],"wp:attachment":[{"href":"https:\/\/biomotion.pbisllc.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}